CLINICAL VALUE OF SERUM PREALBUMIN IN TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION OF PRIMARY LIVER CANCER (

Objective To observe the peri therapeutical changement of serum prealbumin(PA) in primary liver cancer patients underwment transcatheter arterial chemoembolization (TACE).Methods The clinical materials of 150 unresectable primary liver cancer patients underwent TACE were analyzed retrospectively,the peri therapeutical serum level of PA and the correlationship between PA and routinal liver function test were investigated.Result After TACE,there were 26 patients(17.33%)suffered from liver function failure,among which,3 patients died(2%).The serum level of PA decreased significantly at the first day after TACE,and it still decreased to the lowest degree of 8.6±3.5 mg/dl in average about 1 week after TACE,then it began to rise gradually to its pre therapeutical level about 4 weeks after TACE.The abnormal rate of PA after TACE was much higer than those of ALB and Tbil.The PA level of pre treatment and 1 week after treatment in patients underwent 3 times TACE were 13.2±3.0 mg/dl and 6.9±3.3 mg/dl respectively.As compared with chose of patients underwent 1 or 2 time TACE,the difference was signficant.The serum level of PA at 1 week after treatment in patients accepted routinal TACE(6.7±2.4 ng/dl) was much lower than that of patients underwent segmental TACE (10.7±3.4 mg/dl)( P 0.01).The serum level of PA at 1 week after treatment in patients with or without portal vein cancer thrombus were 12.4±2.1 mg/dl and 5.8±1.9 mg/dl or 16.7±3.3 mg/dl and 9.2±3.5 mg/dl respectively,there were significant difference between each other( P 0.01).Conclusion The damage of liver function resulted from TACE will be more severe if lipidol amount and the times of TACE become much more and if the there is cancer thrombus in portal vein,the damage can be declined if we adopt segmental TACE.The serum value of PA can sensitively and exactly reflect the damage of liver function caused by some factors in TACE,and we can chose some medicine to pretect the liver function in time by testing the serum level of PA.