Application of Protective Ventilation Strategy in Treatment of Acute Respiratory Distress Syndrome

Objective To compare the effects of lung protective ventilation strategy(LPSV) and traditional ventilation strategy on acute respiratory distress syndrome(ARDS),ant to evaluate the clinical value of LPSV.Methods A total of 54 children with ARDS were randomly assigned to a conventional ventilation strategy(n=27,group A)or a protective ventilation strategy(n=27,group B).The ventilator settings,blood gas analysis results,oxygenation indexes,complications,duration of ventilator use and length of hospitalization were compared between the two groups.Results Compared with group A,LPSV significantly decreased peak airway pressure,tidal volume,incidence of pneumothorax and lung injury,duration of ventilator use and length of hospitalization,but obviously increased PaCO2 and oxygenation indexes(P0.01 or P0.05).There were no significant differences in PaO2 and case-fatality rate between group A and group B(P0.05).Conclusion The treatment with LPSV is relatively safe and effective for ARDS,and can improve lung oxygenation,maintain adequate PaO2,reduce ventilator-associated complications and shorten the duration of ventilator use and length of hospitalization.