Lung protective strategies of ventilation in respiratory distress syndrome of neonates.

Objective To investigate the advantages of protective ventilation strategies in NRDS and the value of decreasing the incidence of ventilator-associated lung injury (VALI). Methods 60 NRDS neonates who needed ventilator support during 2003 to 2005 were divided into two groups randomly, the experimental group (n = 30) using protective ventilation strategies and the controlled group (n = 30) with traditional ventilation strategies. The ventilator settings, artery blood gas analysis, ventilator-associated lung injury and other clinical data were collected and analyzed. Results The incidence of VAL! in experimental group was significantly lower than that in controlled group (3. 33% vs 20. 00%, P0. 05). PaCO2 in experimental group was significantly higher than controlled group (P0. 05). No differences were found between the two groups regarding to the length of ventilator support, length of supplemental oxygen requirements, length of hospitalization, incidence of PDA and IVH. The mortality in the experimental group was significantly lower than that in controlled group (P0. 05). Conclusions The protective ventilation strategies can decrease the incidence of VALI and the mortality in NRDS neonate.