Application of lung protective ventilation strategy as the therapy for premature severe respiratory distress syndrome

Objective To evaluate the clinical significance of lung protective ventilation strategy in treating premature severe respiratory distress syndrome(RDS).Methods A total of 64 infants with premature severe RDS in our NICU from January 2004 to December 2011 were divided into two groups,research group(36 cases) which was applied with lung protective ventilation strategy,and control group(28 cases) which was applied with conventional ventilation strategy.Parameters of ventilation,blood gas analysis,complication rate,mortality,duration of oxygen,ventilation use and hospitalization were compared between two groups.Results In peak stage of RDS,peak inspiratory end positive pressure(PIP),mean airway pressure(MAP),fraction of inspired oxygen(FiO2),inspiratory rise time(Ti),arterial pH,pressure of oxygen(PO2) in research group were significantly lower in research group than those in control group(P0.05).In comparison with control group,positive end expiratory pressure(PEEP),breath frequency(RR),arterial pressure of carbon dioxide(PCO2) in research group were significantly higher(P0.05).Incidence of ventilator-associated lung injury(VALI),duration of oxygen,ventilation use and hospitalization were significantly lower in research group than those in control group(P0.05),while pulmonary hemorrhage,chronic lung disease(CLD),patent ductus arteriosus(PDA),intraventicular hemorrhage(IVH) and mortality showed no significant diffe-rence.Conclusions Using lung protective ventilation strategies for the premature severe respiratory distress syndrome can significantly reduce the incidence of VALI,shorten the duration of oxygen treatment,ventilation use and hospitalization.It does not increase the complication rates of CLD,PDA and IVH.