Application of Lung Protective Ventilation Strategy in Ventilation Therapy for Neonatal Acute Respiratory Failure

Objective To evaluate the role of lung protective ventilation strategy in the ventilation therapy for neonatal acute respiratory failure.Methods A total of 48 neonatal patients with acute respiratory failure who met the indication of ventilator use were divided into two groups: group A (n=23),applied with conventional ventilation strategy;and group B (n=25),applied with lung protective ventilation strategy.Observation indicators included: fraction of inspired oxygen (FiO2),peak inspiratory end positive pressure (PIP),positive end-expiratory pressure (PEEP),mean airway pressure (MAP),tidal volume (VT),arterial pH,arterial partial pressure of oxygen (PaO2),arterial partial pressure of carbondioxide (PaCO2),incidence and mortality of ventilator-associated lung injury (VALI),intraventricular hemorrhage (IVH),patent ductus arteriosus (PDA),pulmonary hemorrhage (PH),and duration of ventilator use and hospitalization.Results PIP,MAP,and VT were significantly lower in group B than in group A (P0.001),while PaO2 showed no significant difference (P0.05).The incidence of VALI was significantly higher in group A than in group B (P0.05),while IVH,PDA,and PH were not significantly different between two groups (P0.05).The duration of ventilator use and hospitalization were significantly longer in group A than in Group B (P0.05).Conclusion For neonatal acute respiratory failure,lung protective ventilation strategy can decrease the incidence of VALI and shorten the duration of ventilator use and hospitalization,and therefore is a relatively safe and effective ventilation strategy.