2009•Xinxueguan kangfu yixue zazhiRequires access
Effects of simvastatin combined with clopidogrel on hs-CRP and blood lipids in patients with acute coronary syndrome
Shao-Wei Chen
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Abstract
Objective:To investigate the effects of simvastatin combined with clopidogrel on high sensitivity C-reactive protein(hs-CRP) and blood lipids in patients with acute coronary syndrome(ACS).Methods:A total of 117 patients with ACS were divided into two groups: simvastatin group(48 patients) and simvastatin combined with clopidogrel group(69 patients).The levels of hs-CRP and blood lipids were detected before and six-week after treatment.Results:The hs-CRP and blood lipids levels of patients significantly decreased in two groups(P0.01 all).Compared with simvastatin group,the hs-CRP levels significantly decreased(P0.05),but the blood lipids levels had not significant decreased(P0.05)in simvastatin combined with clopidogrel group.Conclusion:Treatment with simvastatin combination with clopidogrel not only decrease the blood lipids levels but also has the best effects on lowering hs-CRP.It suggest that it may inhibit inflammatory responses,increase atherosclerotic plaque stabilization in ACS patients.