Curative Effect Observation of the Progress Acute Cerebral Infarction Treated by Argatroban

Objective Discuss, Argatroban in treatment of acute cerebral infarction clinical curative effect and its possible mechanism. Methods 56 patients with acute progressive cerebral infarction were randomly divided into treatment group, argatroban(the treatment group, 26cases) and routine treatment group(control group, 30cases). Treatment group was given intravenous drip, Argatroban, began to 2 days, 60 mg daily, continuous intravenous drip, the following 5 days, 20 mg daily, morning and evening each once, after 7 days give aspirin, Ozagrel sodium, in accordance with edaravone in treatment, etc. Control group don't have to, argatroban, other are the same as the treatment group. NIHSS score of two groups of treatment for 14 days, and watch the blood coagulation function index changes and adverse reactions during the observation period treatment. Results 14 d after treatment of neural function defect score than before treatment in both groups were improved(P0.01).The treatment group neural function defect score significantly lower than the control group(P0.01). Treatment group patients with nerve function defect score reduction value is significantly higher than the control group(P0.05). In the two groups had no obvious adverse reactions.Conclusion Application in argatroban of acute progressive cerebral infarction treatment is safe, effective.