Clinical Research of Argatroban in the Treatment of Progressive Cerebral Infarction

Objective:To evaluate the efficacy and safety of argatroban in the treatment of progressive cerebral infarction,and to investigate the effective treatment on progressive cerebral infarction.Methods:60cases of progressive cerebral infraction were randomly divided into two groups:argatroban treatment group(n=30)and conventional treatment group(n=30).Treatment group was treated with venous argatroban and Safflower injection.Conventional treatment group was given venous Safflower injection and Sodium Ozagrel.During treatment,two groups were regulated blood sugar and blood pressure,and other neurotrophic drugs treatment according to the basical diseases.NIHSS scores(main index)and improved RANKIN scores were given after treatment of 14d.Adverse events were recorded in the process of treatment.Results:The scores of NIHSS and improved RANKIN with argatroban had statistically greatly improved than the scores before curing(P0.01).The results of ozagrel also showed a remarkable improvement in NIHSS and improved RANKIN(P0.05).The effective rate of the two groups:the argatroban group is 93.3% and the ozagrel group is 76.7%.The rate of the two groups had no significant difference(P0.05).The two durgs are both effective to the treatment of PCI.Therapeutic evaluation of argatroban group is better than that of ozagrel group.Conclusion:Argatroban could greatly improve patients' neurological symptoms.In a word,argatroban is a safe and effective drug for patients with progressive cerebral infarction.