Clinical effectiveness and safety of levamlodipine in treatment of patients with mild to moderate essential hypertension

Objective To evaluate the clinical effectiveness and safety of levamlodipine in treatment of patients with mild to moderate hypertension.Methods Sixty-one patients with mild to moderate hypertension were divided into two groups randomly:test group(levamlodipine,2.5mg/d)and control group(losartan,50mg/d).Patients took their pills for 8weeks.Blood pressure,heart rate and side effects were observed every two weeks.The levers of fasting blood glucose and insulin,cholesterol,triglyceride,aminotransferases,bilirubin,creatinine were determined before and after the treatment.Results Levamlodipine was effective in reducing systolic blood pressure from(145±12)mmHg to(123±10)mmHg(P0.05),and diastolic blood pressure from(96±7)mmHg to(81±7)mmHg(P0.05).The systolic blood pressure and diastolic blood pressure were decreased significantly in losartan group too.Two drugs didn′t affect the levers of glucose,cholesterol triglyceride either.Conclusion Levamlodipine is effective,sate and well tolerated in patients with mild to moderate hypertension without affecting lipids and glucose homeostasis.