2010•Yati yasui yazhoubingxue zazhiRequires access

Baicalin extract affects the inhibitory effects of Porphyromonas gingivalis extracellular vesicles on DNA synthesis of human periodontal ligament fibroblasts

NI Long-xin

Abstract

AIM:To investigate the effect of baicalin extract on DNA synthesis of human periodontal ligament fibroblasts(HPDLFS) under Porphyromonas gingivalis extracellular vesicles(ECV) stimulation.METHODS:Cultured HPDLFS were stimulated with 50μg/mL ECV or ECV plus different concentrations of baicalin for 36 h.HPDLFS with no stimulation served as the control.3H-TdR incorporation method was used to examine the synthesis of DNA in HPDLFS.RESULTS:DNA synthesis of HPDLFS in ECV group was significantly inhibited(P 0.05).Baicalin dose-dependently increased DNA synthesis of ECV-treated HPDLFS and 2 μg/mL baicalin showd statistically significant stimulating effects(P 0.05).CONCLUSION:Baicalin extract shows inhibitory effect on ECV,suggesting that it might be useful in the treatment of periodontal diseases.

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Key concepts: Baicalin, Periodontal fiber, Porphyromonas gingivalis, Stimulation, Chemistry, Extracellular, Pharmacology, DNA