Distribution and Drug Resistance of Pathogens Isolated from Blood Cultures in 2010 from a Certain 3A Hospital

Objective To investigate the distribution and drug resistance of pathogens isolated from blood cultures in 2010,and to provide an optimal antimicrobial therapy.Methods Blood samples were cultivated with BACT/ALERT 3D automated blood culture system,bacterial confirmatory and antibiotic susceptibility tests were carried out with VITEK 2 Compact bacterial identification system.Results A total of 331 strains of pathogenic bacteria were isolated from 6 742 blood cultures,including 174(52.6%) strains of gram positive cocci,142(42.9%) strains of gram negative bacilli and 16(4.8%) strains of fungi.The leading pathogens were CNS,E.coli,Klebsiella,Streptococcus and Enterococcus,accounting for 27.5%,21.1%,7.6%,7.6%,7.3% respectively.The rates of MRSA and MRCNS in Staphylococcus were 33.3% and 91.1%,and the strains were sensitive to vancomycin,minocycline,rifampicin.The detectable rates of E.coli,Klebsiella of ESBLs were 65.7% and 52.0%,and the strains were sensitive to imipenem,meropenem and amikacin.Conclusion It is diversiform and seriously resistant in nosocomial bloodstream infections,thus,we should enhance the drug resistance monitoring and select an optimal antimicrobial therapy.