Research the Effects of Penetration Enhancers on the Water-soluble Matrix Preparati on Navel Hole in Transdermal Drug Delivery Point

Objective:To investigate the effects of the three types of penetration enhancers on the water-soluble matrix preparation navel hole in transdermal drug delivery point,for the navel hole in transdermal drug delivery formulations suitability of the new reference. Methods: Different concentrations of penetration enhancer of water-soluble matrix preparation,select the mouse abdominalskin,using Franz diffusion cell in vitro penetration experiments using highperformance liquid chromatography to receive fluid index constituents paeoniflorin. Results: The penetration enhancers Azone group glycerol gelatin patches significantly promote the role of permeability,water-soluble Azone 3 percent of pro-penetrating best; DMSO to promote penetration is not obvious. Conclusion: The percutaneous absorption was correlated with time; penetration enhancers Azone group and blank group,through the volume there are significant differences(P 0. 05);in which water-soluble Azone group was higher than the corresponding fat-soluble Azone group.