Effect of Penetration Enhancers on the Transdermal Penetration of Peoniflorin in the Liaojin Membrares

Objective:To study the effect of penetration enhancers on the transdermal penetration of peoniflorin in the Liaojin membrares.Methods:We firstly established the experimental method of transdermal penetration,and the methodology study was carried out at the same time.Furthermore,we added 1%Borneol,3%Borneol,8%Borneol,1% Azone,3% Azone and 5% Azone,3% 1,2-Propanediol,5% 1,2-Propanediol,10% 1,2-Propanediol,1% Azone+8%Borneol,3% Azone+8%Borneol,5% Azone+8%Borneol,5% 1,2-Propanediol+8%Borneol,5% 1,2-Propanediol+8%Borneol+3% Azone and 10%1,2-Propanediol+8%Borneol+5% Azone into the membrares.The cumulative penetration amounts and anatonosis multiple were determined during the test of transdermal penetration.Results:The cumulative penetration amounts and anatonosis multiple released from the membrares increased,and the effect to use mix penetration enhancers was far superior compared with penetration enhancers alone.Conclusions:The results indicate that quantitative penetration enhancers can facilitate drug through corneum into dermis,but to use mix penetration enhancers is far superior compared with penetration enhancers alone.