2016•Shiyong yaowu yu linchuangRequires access
Effects of penetration enhancers on percutaneous permeability of miconazole nitrate in Junke cream
Dong Wen-shen, Zhi Lin, Lin Yang, Falin Qu
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Abstract
Objective To study the effects of penetration enhancers on percutaneous permeability of miconazole nitrate in Junke cream, and to screen for the best transdermal absorption and amount. Methods Franz diffusion cell method was used and isolated nude mice skin was as the percutaneous barrier, the content was detected by HPLC,and the cumulative permeation quantity was calculated. Results The cumulative permeation quantity showed that the rank order of absorbefacient effect in different penetration enhancers was as follows: 3% azone > 5% propylene glycol> 5% oleic acid > 3% menthol > without penetration enhancer; the rank order of absorbefacient effect in different dosage of azone was as follows: 5% azone > 3% azone > 1% azone > Junke. Conclusion All the penetration enhancer can enhance the transdermal absorption of miconazole nitrate in Junke cream,and the best penetration enhancer is azone, in which,5% azone has the most obvious effect.