Drug-Induced Hepatic Injury:Literature Analysis of 156 Cases

OBJECTIVE:To discuss the characteristics and clinical manifestation of drug-induced hepatic injury for clinical reference about drug use.METHODS: The drug-induced hepatic injury cases reported in literature over the past 3 years were collected,classified and analyzed statistically.RESULTS: Of the 156 cases,the patients aged ≥60 took the lead,with 60 cases(38.46%);92(58.97%) were induced via oral administration.A total of 13 categories including 61 drugs were involved,with anti-infective drugs(54/156,34.62%),cardio-cerebrovascular drugs(28/156,17.95%) and central nerve system drugs(20/156,12.8%) leading the first 3 places.CONCLUSION: A great variety of drugs can induce liver injury.The non-specificity in clinical manifestation of drug-induced liver injury,the possibility of its misdiagnosis and missed diagnosis and the fact that it is more common in patients with basic liver disease,great importance should be attached to the monitoring on the related drugs to improve rational drug use level.