2009Zhongguo yiyuan yongyao pingjia yu fenxiRequires access

Drug-induced Liver Injury:An Analysis of 371 Cases

Liu Weijun

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Abstract

OBJECTIVE: To conduct a statistical analysis on 371 drug-induced liver injury cases for references of clinical rational drug use and drug safety evaluation.METHODS: In this retrospective study,a total of 371 drug-induced liver injury cases were analyzed with regard to patients' sex and age,medication,manifestation of side effects,and prognosis.RESULTS: A total of 12 categories(57 kinds) of drugs were involved in the 371 drug-induced liver injury cases,leading the first three places were all anti-tuberculosis drugs.CONCLUSION: Great attention should be attached to drug-induced liver injury to prevent adverse drug reactions.

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What this paper is about

OBJECTIVE: To conduct a statistical analysis on 371 drug-induced liver injury cases for references of clinical rational drug use and drug safety evaluation.METHODS: In this retrospective study,a total of 371 drug-induced liver injury cases were analyzed with regard to patients' sex and age,medication,manifestation of side effects,and prognosis.RESULTS: A total of 12 categories(57 kinds) of drugs were involved in the 371 drug-induced liver injury cases,leading the first three places were all anti-tuberculosis drugs.CONCLUSION: Great attention should be attached to drug-induced liver injury to prevent adverse drug reactions.

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Available abstract

OBJECTIVE: To conduct a statistical analysis on 371 drug-induced liver injury cases for references of clinical rational drug use and drug safety evaluation.METHODS: In this retrospective study,a total of 371 drug-induced liver injury cases were analyzed with regard to patients' sex and age,medication,manifestation of side effects,and prognosis.RESULTS: A total of 12 categories(57 kinds) of drugs were involved in the 371 drug-induced liver injury cases,leading the first three places were all anti-tuberculosis drugs.CONCLUSION: Great attention should be attached to drug-induced liver injury to prevent adverse drug reactions.

Key concepts: Drug, Liver injury, Medicine, Adverse drug reaction, Drug reaction, Pharmacology, Statistical analysis, Retrospective cohort study

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