Clinical Analysis of 225 Cases of Drug Hepatic Damage

Objective To analyze the etiology,clinical characteristics and prognosis of drug hepatic damage,and to evaluate the efficiency of the treatment,in order to improve the understanding of the drug hepatic damage,and so as to promote the clinical rational drug application.Methods The basic situation,the medical history and clinical characteristics of 225 hospitalized patients in 2005-2011 with hepatic damage were retrospectively analyzed,and the possible mechanism was discussed.Results The top 4 drugs that cause drug hepatic damage were antitumor drugs(35.1%),Chinese herbal medicine(19.2%),anti-infective(10.3%) drugs,cardiovascular drugs(10.3%).The main clinical manifestations were as follow: abdominal distension,abdominal pain,anorexia,jaundice.Liver cell damage was the most common type of liver damage.Conclusion There are many kinds of drug that can cause hepatic damage,and there were no specific clinical manifestations.Therefore the clinical application of drugs should strictly be accordance with its indication,to prevent the occurrence of drug hepatic damage.