Expression of tumor-associated mucin MUC1 in human ovarian epithelial neoplasms and its clinical significance

Objective To investigate expression of tumor-associated mucin MUC1 in human epithelial ovarian neoplasms with different degrees of differentiation and its clinical significance,so as to explore early diagnosing method of malignant ovarian tumors.Methods Immunohistochemistry was used to detect expression of MUC1 in 100 cases of human ovarian epithelial neoplasms and association of expression of MUC1 with clinical manifestations and pathological changes was analyzed.Results ①MUC1 was expressed in epithelial ovarian neoplasms and the expression was increased orderly in benign ovarian tumors,borderline ovarian tumors and malignant ovarian tumor(ovarian carcinoma).The positive expression rate of MUC1 was increased with increases of malignance degree of the neoplasm.② The expression of MUC1 was not correlated with intraoperative pathological staging,invasion to surrounding tissues,pathological classification of the neoplasm(all P0.05) with it was correlated significantly with pathologic differentiation degree and lymphatic metastasis of the neoplasm.The lower the differentiation degree of the tumor,the higher the expression of MUC1.Conclusion MUC1 is correlated closely with occurrence and development of ovarian carcinoma.As a new tumor marker,MUC1 is of important significance for estimating canceration potential danger of borderline ovarian epithelial neoplasms and prognosis of ovarian carcinoma.