Effects of Rosiglitazone on Expression of BNP after Acute Myocardial Infarction in Rats

Objective To study the effect of rosiglitazone on BNP after myocardial infarction in rats.Methods Sixty-five healthy male Wistar rats were randomly divided into sham operation group(n=15)and AMI group(n=50).Rats in the AMI group were induced by left anterior descending branch ligation.Thirty six rats survived 24 hours later,and were then randomly divided into AMI control subgroup(n=18)and rosiglitazone administered subgroup(n=18).Rats in rosiglitazone administered subgroup were treated with rosiglitazone(gastric lavage,4mg/(kg·d)for 4 weeks,and rats in AMI control subgroup and sham operation group were treated with only physiological saline.6 weeks later,we compared the difference of the heart weight index and the left ventricular weight index among the three groups,and the expression of BNP mRNA was detected by Real Time PCR.Results Compared with the shame operation group,the heart weight index,the left ventricular weight index and the expression of BNP mRNA were significantly increased in rosiglitazone group and myocardial infarction group(P0.05).And the left ventricular weight index and the expression of BNP mRNA were apparently decreased in rosiglitazone group compared with myocardial infarction group(P0.05).Conclusion Rosiglitazone can reduce the expression of BNP mRNA and the process of myocardial hypertrophy after myocardial infarction,and then improve the ventricular remodeling.