Clinical Study on Patients with Advanced Gastric Cancer Treated with OLF Regimen

ObjectiveTo evaluate the efficacy and toxicity of oxaliplatin(OXA) in combination with 5-fluorouraeil(5-Fu) and leucovorin(LV) in the treatment of advanced gastric cancer.Methods26 patients with advanced gastric cancer enrolled.All patients received modified OLF regimen,namely OXA 130 mg/m2 iv 4 h d1,LV 200 mg/m2 iv 2 h d1-5,5-Fu 300 mg/m2 iv 6 h d1-5,repeated every 3 weeks.The efficacy and toxicity were evaluated according to WHO standard.ResultsAll patients might be evaluated for clinical response,CR was observed in 1 patient(3.8%) and PR in 8(30.8%),SD in 8(30.8%),PD in 9(34.6%).The total response rate(CR+PR) was 34.6%.Median time to progression(TTP) was 5.2 months,median overall survival time(MST) was 8.6 months.The most common toxicities were nausea,vomiting,suppression of marrow and mild neuro-sorv abnormity.There was no treatment related death.ConclusionOXA in combination with 5-Fu and LV is an effective and well tolerated regimen in the treatment of advanced gastric cancer with mild toxicity.