Clinical observation of the effects of flurbiprofen axetil combined withdexamethasone analgesia on patients undergoing laparoscopic cholecystectomy

Objective To investigate analgesia effect of flurbiprofen axetil combined with dexamethasone on postoperative pain and postoperative nausea and vomiting. Methods Two hundred and forty patients undergoing selective LC operation were randomly assigned into three groups: group A received flurbiprofen axetil 1 mg·kg- 1combined with dexamethasone 10 mg,group B flurbiprofen axetil 1 mg·kg- 1and group C physiological saline 5 mL. Visual analgesia scale( VAS),side effects were recorded at 1,3,6,12,24 h after operation. Results VAS in group A and B were lower than group C at each time point( P 0. 05); VAS in group A was lower than group B at 6,12,24 h time point( P 0. 05). The incidence of nausea and skin itching in group A were lower than those in group B and C( P 0. 05). There were no difference between group B and C( P 0. 05). Conclusions Flurbiprofen axetil combined with dexamethasone can extend the time of postoperative analgesia and reduce the adverse effect,which has synergistic analgesia effect.