The relationship between Hp infection and serum lipid or CRP levels in patients with CHD.

Objective To investigate the relationship between helicobacter pylori(Hp) infection and serum lipid or C-reactive protein(CRP) levels in patients with coronary heart disease(CHD).Methods Serum specific antibodies to Hp(Hp IgG),serum lipid and CRP were measured in healthy subjects(control group,n=35) and patients with CHD,including patients with acute myocardial infarction(AMI group,n=35) and angina pectoris(AP group,n=35).Results The positive rate of Hp IgG was 54.3% in AMI group,45.7 % in AP group and 25.7% in control group,The positive rate of Hp IgG was significantly higher in patients with AMI or AP than in control group(P0.05).Serum CRP,total cholesterol(TC),triglycerides(TG),low density lipoprotein cholesterol(LDL-C),apolipoprotein A(apo A) were significantly higher in patients with CHD than in control group(all P0.01),while high density lipoprotein cholesterol(HDL-C) was significantly lower in patients with CHD than in control group(P0.01),HDL-C was significantly lower in patients with AMI than in patients with AP(P0.01).Hp IgG was positively correlated with CRP,TG,LDL-C and apo A(r=0.44,0.64,0.36 and.32,respectively) but negatively correlated with HDL-C in patients with CHD(r=-0.78,P0.01).Conclusion Hp infection rate is significantly higher in patients with CHD.Hp infection may play a role in the pathogenesis of CHD through inflammatory reaction and lipid metabolic disturbance.