Effects of Helicobacter pyloriinfection in serum inflammatory factors in coronary heart disease

OBJECTIVE To explore the effects of Helicobacter pylori(Hp) in serum inflammatory factors in coronary heart disease(CHD).METHODS Forty five cases with CHD were selected as CHD group and 30 healthy cases as control group.Serum specific antibodies to Hp(Hp-IgG),serum sICAM-1,IL-6 and hs-CRP were measured in control group and CHD group by ELISA.The relationship of Hp and the expression of serum sICAM-1,IL-6 and hs-CRP were analyzed.RESULTS The positive rate of Hp IgG(75.6%) and the expression of serum sICAM-1(509.56±63.45),IL-6(37.29±14.69) and hs-CRP(8.26±3.68) in CHD group were significantly higher than those in control group(50.0%,154.24±27.39,15.63±6.84,4.72±2.38)(P0.05).In CHD group,those who were Hp IgG positive had significant higher levels of sICAM-1(615.86±89.45),IL-6(44.09±13.49) and hs-CRP(10.52±3.48) than those who were Hp IgG negative(395.72±71.49,25.93±9.83,5.91±2.18)(P0.05).CONCLUSION There is significant corelation between Hp infections and CHD.Hp infections may be involved in the pathogenesis of atherosclerosis and myocardial infarction by increasing the expression of sICAM-1,IL-6 and hs-CRP and aggravating coronary artery inflammation.