Relation of Helicobacter Pylori Infection and Coronary Heart Disease

Aim To investigate the relation of Helicobacter pylori(HP) infection and coronary heart disease (CHD) and the effects on lipid metabolism and serum immunology. Methods HPIgG(ELISA) and IgG,IgA,IgM,C3,CIC, and total cholesterol(TC),triglyceride(TG),apolipoprotein A(ApoA),apolipoprotein B(ApoB) were measured in 90 cases of CHD,with 40 healthy subjects as controls. Results The rate of seropositive for HPIgG in CHO patients is significantly higher than that of controls(5319% vs 275%,P001). In the cases of acute myocardial infarction(AMI) and unstable angina pectoris(UAP) the rate of seropositive for HPIgG is higher than that in the cases of other types of CHD(P005). For the cases of CHD,the level of serumTG in these of HP seropositivity is higher than that of HP seronegativity(P005).The level of serum IgG and CIC in the cases are much higher than that in controls(P001). Regression analysis indicates that the HP infection is related positively to CHD(P=0047). No correlation between HP infection and other risk factors was found. Conclusion HP infection may be associated with CHD. HP infection may act through immunoreaction or changes in lipid metabolism contributing to the pathogenesis of CHD.