MSCT perfusion imaging in evaluation of restorability of rabbits renal function of hydronephrotic kidney

Objective To assess the value of MSCT perfusion in the restorability of renal function of hydronephrotic kidney due to completed unbilateral uterus obstruction. Methods Forty-eight healthy adult male rabbits were randomly divided into 4 groups as 1 week group,3 weeks group,5 weeks group and 7 weeks group (1 w,3 w,5 w,7 w,each n=10). Then rabbits in every group were randomly divided into sham-operated subgroup and obstruction subgroup. Rabbits in obstruction subgroups were operated as complete ureteral obstruction and renal water model,and in sham-operated subgroups were operated as same as obstruction subgroups except ureter being not ligated. MSCT perfusion imaging and SPECT examination were performed before operation and at each obstruction time to detect the left renal cortical blood flow (BF),blood volume (BV),time to peak (TTP) and glomerular filtration rate (GRF). Then obstruction was lifted,and MSCT perfusion imaging and SPECT examination were performed again after 2 months. One rabbit was sacrificed in every stage for pathological examination. Results ①There was no significant difference (P0.05) of BF,BV,TTP (P0.05) before and after surgery of sham-operated subgroups at different time periods. After obstruction,BF,BV value reduced gradually with time prolonged. There was no statistical difference of the BF,BV value among the 4 groups before the obstruction being relieved (P0.05). After lifting obstruction,the BF,BV value of 1 w restored to near preoperative levels (P0.05),but not recovered in 3 w(P0.05),while no statistical difference was found in 3 w (P0.05). BF,BV value of 5 w and 7 w continued to decrease,and the differences were statistically significant (P0.05) compared with obstruction being relieved and before operation. After obstruction,TTP value of 1,3 and 5 w gradually extended (P0.05) with the period being prolonged,no statistical difference was found between 5 w and 7 w,as well as between each group and after lifting the obstruction (all P0.05). ②There was no significant difference for GRF value between pre-and post-operation for sham-operated subgroups (P0.05),none between sham-operated subgroups and obstruction subgroups for preoperation,before and after lifting the obstruction (P0.05). Statistical difference was also found between 1 w,3 w,5 w and 7 w groups for GRF value before the obstruction being relieved. ③With obstruction time prolonged,tubular expansion increasingly clear and the degree of renal fibrosis increased gradually. Conclusion After complete unilateral ureteral obstruction,when the BF,BV value of hydronephrotic kidney cortical decreased to (312.21±26.35)ml/(100 g·min),(10.76±5.37)ml/(100 g),the renal function is difficult to restore to normal levels. MSCT perfusion imaging can provide valuable information for evaluating the capability of renal function recovery before operation