Predictability of multi-slice CT perfusion in the restorability of renal function of hydronephrotic kidneys

Objective To evaluate the predictability of MSCT perfusion in the restorability of renal function of hydronephrotie kidneys with unilateral partial ureteric obstructed rabbit model as to explore a method to predict the restorability of renal function of hydronephrotic kidneys and to investigate the changes of MSCT perfusion parameters during the course of the restore of renal function.Methods Establish a unilateral partial ureteric obstructed rabbits hydronephrotie model.Hydronephrotie rabbits were grouped as control,2,4 and 8 week(G_2w,G_4w and G_8w)after obstruction and the later 3 groups of rabbits were reared for further 4 weeks after the obstruction was released.MSCT perfusion scanning was performed and the specimen was made into histological slices with HE staining.Results BF and BV value of renal cortex and medulla of G_2w after obstruction [(864±32)ml·100 g~(-1)·min~(-1),(19.5±0.9)ml/100 g (cortex ); (182.1±7.5)ml·100g~(-1)·min~(-1),(8.37±0.51)ml/100g(medulla)]was released restored in substance and approached that of control[(899±63)ml·100g~(-1)·min~(-1),(21.6 + 1.4)ml/100 g (cortex);(193.5±16.5 )ml·100g~(-1)·min~(-1),(8.50±0.54 )ml/100 g (medulla)]while there was no significant restore in that of G_4w and G_8w after obstruction[(525±15)ml·100g~(-1)·min~(-1),(12.8± 0.6)ml/100g (G_4 w);(512±10)ml·100g~(-1)·min~(-1),(9.4±1.0)ml/100 g (G_8w)] was released. Histologically,there was a positive correlation between the duration of obstruction and the seriousness of pathologic changes.Conclusion MSCT perfusion can provide information not only morphologically but also about renal perfusion of hydronephrotic kidneys.