The Value of MSCT Perfusion in the Half Functional Assessment of Hydronephrotic Kidney:An Experimental Study

Objective To evaluate the usefulness of MSCT perfusion in assessment of half renal function of hydronephrotic kidney.Methods Twenty healthy adult male rabbits aged more than 8 weeks with experimentally induced partial obstruction of right ureter underwent sequential MSCT perfusion and SPECT pre-obstruction and post-obstruction of ureter 4 weeks later.Results After ureteral obstruction 4 weeks later,pelvicalyceal dilatation and renal parenchymal thinning were seen on MSCT,blood flow (BF)and blood volume(BV) were significantly lower than those in before ureteral obstruction(P0.01).Mean transit time(MTT)was no significant changes and permeability surface(PS) of renal cortex was slightly lower than that before obstruction but no significant,while PS of renal medulla was significantly lower than that before obstruction (P0.01).On SPECT,glomerular filtration rate(GFR)of the obstructed kidneys were much lower than those before the obstruction(P0.001),Tb was much longer(P0.001) and T1/2 was much longer which had no practical significant in measurement.Conclusion MSCT perfusion is of certain value in evaluating the half renal function of hydronephrosis.