Predictability of MSCT perfusion imaging in the restoration of renal function of hydronephrotic kidney in rabbits

Objective To evaluate the value of multi-slice spiral computed tomography(MSCT)perfusion imaging for evaluating the restoration of renal function of hydronephrotic kidneys in rabbits with unilateral partial ureteric obstruction.Methods Twenty-four healthy adult male rabbits were involved in the study,aged more than 8 weeks and weighed 2.0-3.0 kg.Six were selected at random as controls.The other eighteen were induced to establish the partial obstruction model of left ureter,and were randomized into 3 groups according to different obstruction time:1 week group(n=6),3 week group(n=6),5 week group(n=6),and then all rabbits were performed MSCT scanning.After the obstruction was released,the model rabbits were fed for 3 months and then performed MSCT scanning.The histological changes were observed at different obstruction time by HE.Results After partial ureteric obstruction,blood flow(BF)and blood volume(BV)of the left renal cortex and medulla gradually decreased,and there was significant difference between 4 groups(P0.05).BF and BV value of left renal cortex and medulla in 1 week group increased significantly after the release of obstruction(P0.05),but no significant difference was found between in 1 week group and control group(P0.05).BF and BV value of left renal cortex and medulla in 3 week group showed no significant change after the release of obstruction(P0.05),but significant lower than in control group.BF and BV value of left renal cortex and medulla in 5 week group decreased significantly after the release of obstruction(P0.05),and significantly lower than in control group(P0.05).Histologically,there was a positive correlation between the duration of obstruction and the seriousness of pathologic changes.Conclusion MSCT perfusion imaging can provide information not only morphologically but also functionally,and it is valuable for evaluating the restoration of renal function of hydronephrotic kidney.