Combined anluohuaxianwan and adefovir dipivoxil treatment on patients with hepatic fibrosis of chronic hepatitis B.

Objective To study the clinical effect of combined anluohuaxianwan and adefovir dipivoxil treatment on patients with chronic hepatitis B. Methods 60 patients with chronic hepatitis B were randomly divided into 2 groups,namely group A and group B.Group A received a combined treatment with anluohuaxianwan and adefovir dipivoxil, while group B received adefovir dipivoxil only. The therapeutic period was 6 months. The levels of HA,LN,PCIII,IV-C,TBIL,ALT,AST,and HBV-DNA quantity were determined both before and after the treatment. Results After 6 months of treatment, the levels of HA, LN, PCIII and IV-C were lower in both group A and B. The improvement of HA, LN and IV-C in group A was significantly better than those in group B (P0.05). The levels of TBIL, ALT and AST were improved in both group A and B after the treatment, and the improvement of TBIL, ALT and AST in group A was significantly better than group B (P0.05). However,the level of HBV-DNA was lower in both group A and B after the treatment, and the difference in improvement between the group A and B was not significant(P 0.05). Conclusion Combination of anluohuaxianwan and adefovir dipivoxil is effective in the treatment of patients with hepatic fibrosis of chronic hepatitis B.