Drug-resistance of Pseudomonas aeruginosa in Ezhou.

OBJECTIVE To investigate the flora distribution and drug-resistance in nosocomial infections with Pseudomonas aeruginosa(PAE) to provide the scientific accordance for the clinical use of the antibiotics.METHODS PAE was cultured and identified according to the National Clinical Laboratory Operation Rules.Drug susceptibility testing was performed by K-B methods.RESULTS The 244 strains of PAE were mainly isolated from intensive care unit(ICU),department of respiratory medicine,department of neurosurgery and department of chest surgery.Drug-resistance results of PAE to commonly used antibiotics showed that 84.0% of PAE were susceptible to carbapenem such as imipenem and meropenem with the highest susceptibility.The antibacterials with ≥50.0% resistance rate were as followed: SMZ-TMP(95.5%),aztreonam(69.3%),cefotaxime(68.0%),gentamicin(60.7%),ciprofloxacin(59.4%),levofloxacin(54.1%),piperacillin(50.0%) and cefepime(50.0%).CONCLUSIONS The drug-resistance status of nosocomial infections due to PAE is very serious in Ezhou.We should strengthen management of antibiotics to prevent spread of resistant strains and outbreak of nosocomial infections.