Synthesis and Nematicidal Activity of Some Substituted Isoxazoles against Root Knot Nematode (Meloidogyne javanica)

A series of 3-(4-substituted phenyl)-5-(2/4-substituted phenyl) isoxazoles (XIX-XXIX) have been synthesized from 1 -(4-substituted phenyll-3-(4-substituted phenyll-2-propen-1 -one (VIII-XVIII). 3-(4-Hydroxy yhenyl)-5-(2/4-substituted phenyl) isoxazoles (XXVII-XXIX) on refluxing with epichlorohydrin in presence of potassium carbonate afforded 3-(4-oxiranylmethoxy phenyl)-5-(2/5-substituted phenyl)isoxazoles (XXX-XXXII). Further, compounds XXX-XXXII were treated with substituted phenols in presence of alcohol to afford compounds XXXVI-XLIV. All the compounds were characterized and screened for their nematicidal activity in vitro against Meloidogyne javanica at different concentrations. Some of the compounds have shown significant nematicidal activity.