Coagulase Negative Staphylococcus:Clinical Distribution and Drug Resistance of 601 Strains

OBJECTIVE To study the distribution and drug resistance of coagulase negative Staphylococcus(CNS),so as to provide the reference for the rational use of antimicrobial agents.METHODS Totally 601 strains of isolated CNS in recent three years(Jan 2006-Dec 2008) were identified and tested by ATB expression and drug sensitivity system.RESULTS A total of 601 strains of CNS were isolated.The most common pathogens were Staphylococcus epidermidis(33.66%,28.62% and 22.12%),S.hemolyticus(37.62%,36.40% and 29.95%) and S.simalans(6.93%,8.83% and 11.52%).The drug sensitivity rates to penicillin,erythromycin and oxacillin were 2.61%,17.75% and 18.24%,respectively,but to clindamycin and second generation quinolones were both 70%,and to fusidicacid,minocycline and teicoplanin were low.The susceptible rate of CNS to vancomycin was 100%.CONCLUSIONS CNS are the important kinds of pathogens to cause nosocomial infection.The condition of drug resistance of CNS is very severe,laboratory should strengthen the monitoring of the drug resistance and update in time to provide evidence for the rational use of antimicrobial agents and to leave the occurrence of drug resistance.