Analysis of clinical distribution and drug-resistance of 206 strains of Staphylococcus

Objective To analyze the distribution and drug resistance of coagulase negative Staphylococcus(CNS)to enhance the monitoring of hospital infection and provide the reference for rational use of drugs.Method CNS isolated from inpatients from January,2009 to December,2009 were identified with ATB expression microbial identification and drug sensitivity system.Sensitivity of ten kinds of antibiotics like Oxacillin was tested by Kirby-Bauer.Result 206 strains of CNS were distributed in 8 groups of clinical specimens.Isolation rate of samples of generative tract and blood were higher,respectively with the percent of 52.91 and 25.24.The drug-resistantrate to penicillin,erythromycin stood at 85% and 82%.The drug-resistan to clindamycin,second generationquinolones,levofloxacin.The drug-resistant to vancomycin was zero.Conclusion CNS drug resistance isolated in our hospital is serious,MRS occurrence rate is over 59%.Due to high resistance of Erythromycin and Clindamycin,the clinical use of the experience administration,such as penicillin and erythromycin and so on,should be minimized.To prevent the outbreak of resistant strains of hospital epidemic,antibiotics for treatment should be selected to the result of drug resistance analysis.