The protective effect and mechanism of L-carnitine on acute experimental hepatic injury mice and rats induced by CCL4.

[Objective] To investigate the protective effect and possible mechanism of l-carnitine on experimental liver injury of mice and rats induced by CCl4.[Methods] We duplicated the acute and chronic liver injury models with CCl4 by intraperitoneally and subcutaneouly injecting CCl4 for mice and rats respectively.Mice and rats were divided into different groups randomly:normal control groups,model control groups,drug control groups and l-carnitine groups.The level of serum ALT,AST,T-BIL,TP,ALB,A /G and the activity of SOD,MDA,GSH-px,A-SAC and T-AOC in injury liver were detected by automatic biochemistry analyzer.The liver was weighted and the index of liver was calculated.[Results] After treating with different level of LC(0.25-1.0 g·kg-1),the level of serum ALT,AST and liver index obviously decreased(P﹤0.05,P﹤0.01),showed dose-dependent relationship.The activities of SOD,A-ASC and GSH-px(P﹤ 0.05,P﹤ 0.01) was obviously increased.The potential of T-AOC(P﹤0.05,P﹤0.01) was enhanced,reduce the content of MDA(P﹤0.05,P﹤0.01) increased with the decrease of LC(P﹤0.05,P﹤0.01).LC(0.15g·kg-1) could significantly decrease the level of ALT,AST,LI,TP and T-BIL,and incrased the ALB and A /G(P﹤0.01) on chronic hepatic injury in rats,as well as relieve histopathological change of hepatic injury in rats.[Conclusion] LC has a remarkably protective effect on acute and chronic liver injury,and its mechanism has association with its antioxidation.