Protective Effect of Weishusan on Chronic Hepatic Injury Induced by CCL_4 in Rats

Objective To observe the protective effects of Weishusan on chronic hepatic injury induced by CCl 4 in rats. Methods Rat model of chronic hepatic injury was made by CCl 4 The levels of serum AST、ALT、ALB、HA、Hyp and liver pathological tissue were observed.Results The level of serum ALT、AST、HA、Hyp in CCL 4 induced chronic hepatic injury rats all increased Conmpared with normal group(P0.01～0.001)the level of serum ALB decreased(compared with normal group,P0.01)Comparing model group with normal group the chronic hepatic injury rat model was proved to be established successfully. Compared with model group the dosage groups of Weishusan could descrease the serum ALT,AST, HA and the contents of Hyp (compared with model group, P0.05～0.01),increase the level of serum ALB (compared with model group P0.05～0.01) and reduce the range of hepatic pathologic change in rats.Conclusion Weishusan can protect rats from chronic heptic injury caused by CCl 4.