Protective Effect of Carnitine-orotate Against Acute Chemical Liver Injuries Induced by CCl_4

Objective The purpose of this study was to investigate the protective of Carnitine-Orotate against Acute CCl_4–Liver Injuries.Methods Adopt the model of acute CCl_4–Liver Injuries induced by abdominal injection.32 healthy rats were randomly dived into 4 groups: control group(without liver injury),model injury group,low dosage of Carnitine-orotate group and high dosage of Carnitine-Orotate group,each administered relevant medications for 7 days and then were killed.The serum biochemical indicators related the hepatic function and hepatatic histopathological of effect were investigated.Result The serum ALT,AST,ALP,TBil,TG in the high dose were significantly lower than the injury model group.The MDA level was singnificantly lower and the SOD and GSH-PX activity were significantly higher in the high dose than the injury model group.Conclusions Carnitine-orotate posses protective effects on acute CCl_4-Liver Injuries.