An immunohistochemical study on expression of CD44v6 protein in human gallbladder carcinoma

Objective To investigate the clinical significance of CD44v6 protein expression in human gallbladder carcinoma(GBC).Methods The immunohistochemical technique was adopted for detecting the CD44v6 protein expression in 40 cases of GBC,12 cases of chronic cholecystitis,6 cases of adenoma and4 cases of adenomyomatous hyperplasia.Results The positvie rate of CD44v6 expression in gallbladder carcinoma and benign lesions was 72.5%,0% respectively(P0.01),and it also correlated with the lymph node metastasis,pathologic differentiation and clinic staging,but had no correlation with pathological types.Conclusion Detecting CD44v6 expression might be severed as an objective indicator for differential diagnosis,lymph node metastatic potency,tumor progression and prognosis in gallbladder carcinoma.