2009•Zhongguo linchuang baojian zazhiRequires access

The expression of endothelin-1 in ovarian tumors and its clinical implications.

Yi Wang, Sun HangLin, Hu Zhi, Qiong Ye, Feng Ye

Abstract

Objective To investigate the expression of endothelin-1(ET-1) in ovarian tumors.Methods Expression of ET-1 in ovarian tumors(malignant n=56 benign tumor n=19,normal tissue n=17) was evaluated by immunohistochemical staining.Results Expression of ET-1 in ovarian tumors was significantly higher than that in normal tissues(P0.05),Expression of ET-1 in ovarian cancers was significantly higher than that in benign tumors(P0.05).However,ET-1 expression was not correlated with different histological classifications(P0.05),differentiation grade(P0.05) and International Federation of Gynecololgy and Obstetrics(FIGO) stage(P0.05),Conclusion The results indicate that ET-1 plays some role in occurrence of the ovarian tumors.

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Key concepts: Medicine, Immunohistochemistry, Pathology, Stage (stratigraphy), Ovarian tumor, Ovary, Ovarian cancer, Internal medicine