Expression and relationship of OPN and MMP-9 in epithelial ovarian carcinoma.

Objective To study the expression and relationship of osteopontin(OPN)and matrix metalloproteinase-9(MMP-9)in epithelial ovarian carcinoma. Methods Immunohistochemical staining S-P methods was used to detect the expression of OPN and MMP-9 in the samples of 60 epithelial ovarian carcinoma,20 benign ovarian tumor,20 borderline ovarian tumor and 10 normal ovarian tissue. Results The expression level of OPN and MMP-9 in epithelial ovarian carcinoma(109.86±21.51)were significantly higher than those in borderline ovarian tumor(45.81±8.93),benign ovarian tumor(11.86±3.01)and normal ovarian tissue(5.32±2.74). The expression level of OPN and MMP-9 related to the tumor grading,tumor stage and lymph node metastasis,while had no relationship with histological grading. There was significant positive correlation between OPN and MMP-9 in epithelial ovarian carcinoma(r = 0.80,P 0.05). Conclusion The increased expression of OPN and MMP-9 may play an important role in the process of carcinogenesis,progression and differentiation of epithelial ovarian carcinoma. OPN and MMP-9 may be a useful targets for treatment of ovarian carcinoma.