Expression of osteopontin in human epithelial ovarian carcinoma tissue and its significance

Objective To explore the expressions of osteopontin(OPN)in normal ovarian tissue,benign ovarian tumor tissue and epithelial ovarian carcinoma tissue,and to clarify the value of OPN as an indicator to monitor the malignancy degree and evaluate the prognosis of epithelial ovarian carcinoma.Methods The ovarian resection specimens of 100cases were collected,including 20cases of normal ovarian tissue,20cases of benign ovarian tumor tissue and 60cases of epithelial ovarian carcinoma tissue.Epithelial ovarian carcinoma including 30cases of ovarian serous adenocarcinoma,20 cases of ovarian mucinous cystadenocarcinoma and 10 cases of ovarian endometrioid carcinoma.According to the differentiation degree,60cases of epithlial ovarian carcinoma were divided into 12cases well differentiated carcinoma(G1),16cases of moderately differentiated carcinoma(G2),and 32cases of poorly differentiated carcinoma(G3).According to the International Federation of Gynecology and Obstetrics(FIGO)2000primary ovarian cancer surgery-pathological staging criteria,60cases of epithelial ovariancarcinoma including 30cases of epithelial ovarian carcinoma at stageⅠ and Ⅱ,and 30cases of epithelial ovarian carcinoma at stage Ⅲ and Ⅳ.HE staining and immunohistochemical staining were used to detect the OPN expression.Results OPN mainly expressed in the cytoplasm of cancer cells.The positive expression rate of OPN in 60cases of epithelial ovarian carcinoma group was 75.0% which was higher than those in normal ovarian group and benign ovarian tumor group(P0.01).With the increasing of clinical stage,the positive expression rate of OPN was increased;the positive expression rate of OPN in poorly differentiated epithelial ovarian carcinoma group was higher than that in well differentiated epithelial ovarian carcinoma group(P0.01);the positive expression rates of OPN had no significant differences between different histological types of epithelial ovarian carcinoma(P 0.05).Conclusion OPN may contribute to the occurrence,development,invasion,and metastasis of epithelial ovarian carcinoma.OPN is of great significance for the clinical assessment of diagnosis and metastasis of epithelial ovarian carcinoma,and it can be used as an important indicator to monitor the malignancy degree and evaluate the prognosis of epithelial ovarian carcinoma.