Influence of wild chrysanthemum on some neuroendocrine factors in ventricular remodeling induced by abdominal aortic banding in rats.

Objective:To approach the in unce of wild chrysanthemum on some neuroendoerine factors in ventricular remodeling induced by abdominal aortic banding(AAB)in rats.Methods:Myocardial hypertrophy,ventricular remodeling model was induced by abdominal aortic banding(AAB)in rats.After 35 days' treatment,the systolic blood pressure(SBP),diastolic blood pressure(DBP) and mean arterial pressure(MAP) were measured.Then the ratios of LVW/BW(1eft ventricle weight/ body weight),HW/BW(heart weight/body weight)were Calculated.The Angiotensin II(Ang II) content in heart tissue and the Aldosterone(ALD),Tumor Necrosis Factor(TNF-α)concentration of blood plasma were determined by radioimmunoassay.Results:The experimental data demonstrated that wild chrysanthemum could decrease SBP,DBP,MAP and the cardiac indexes of LVW/BW and HW/BW,significantly reduce the content of Ang II,ALD and TNF-α,decrease the Hydroxyproline content(P0.05).Conclusion:Wild chrysanthemum can signi cantly attenuate the experimental ventricular remodeling,the mechanism may be related with its ability to inhibit the activation of rennin-angiontensin-aldosterone system(RAAS)and sympathetic nervous system(SNS),decrease the content of neuroendocrine factors(Ang II,ALD,TNF-α).