Effect of liguzinediol on ventricular remodeling in press-overloaded rats

Aim To examine the effect of liguzinediol on ventricular remodeling induced by pressure overload in rats,as well as to explore the mechanisms involved.Methods The model rats in which ventricular remodeling was induced with abdominal aortic banding(AAB) were randomly divided into 6 groups: Sham group,AAB model group,AAB plus captopril group(10 mg·kg-1),AAB plus liguzinediol groups with various dosages(5,10 and 20 mg·kg-1).After administration of the tested drugs for 8 weeks,SBP,DBP,MAP,LVSP,LVEDP and ±dp/dtmax were recorded.Heart mass index(HMI) and left ventricular mass index(LVMI) were calculated.Isolated rat hearts were observed by hematoxylin-eosin(HE) staining.The concentrations of renin,angiotensinⅡ(AngⅡ) and aldosterone(ALD) in plasma were measured by radioimmunoassay.The content of myocardial tissue hydroxyproline(HYP) was detected by alkaline hydrolysis,and the ratio of Ⅰ/Ⅲ type collagen was exam-ined by ELISA.Results Compared with model group, liguzinediol groups could significantly decrease hemodynamic parameters,HMI and LVMI,improve pathological changes,reduce AngⅡand ALD content in left ventricular tissue,decrease HYP content and the ratio of Ⅰ / Ⅲ type collagen.Conclusion In conclusion,liguzinediol significantly attenuates ventricular remodeling induced by pressure overload in rats.The benefi-cial mechanisms are in part associated with its alleviating the activation of renin-angiotensin-aldosterone system.