Effect of flurbiprofen axetil on multimodal analgesia in patients undergoing laparoscopic cholecystectomy

Objective To assess the multimodal analgesia effect of flurbiprofen axetil with tramadol for patients undergoing laparoscopic cholecystectomy.Methods Sixty patients were randomly allocated to three groups:15 minutes before operation,the patients in group A and B received intravenous of flurbiprofen 1 mg/kg,group C received flurbiprofen 1 mg/kg,10 min before the end of operation;and postoperatively group A received normal saline 20 mL,group B and C received tramadol 1 mg/kg.The effects of analgesia were assessed by visual analogue scale(VAS)at 30 min and 1,2,4,8,12,24 h after operation,and side effects,the overall satisfaction on analgesic therapy were assessed.Results Incisional pain,visceral pain and shoulder-tip pain VAS in group B were lower than those of A and C during 24 h after operation(P0.05).Side effects in 3 groups were similar(P0.05).The overall satisfaction on analgesic therapy were better in group B than that in group A and C(P0.05).Conclusion Flurbiprofen axetil can produce preemptive analgesia,associated with tramadol postoperatively can lead to higher patients′ satisfaction,and is a good choice for the patients after laparoscopic cholecystectomy in multimodal analgesia.