The preemptive analgesic effect of flurbiprofen axetil injection in patients undergoing laparoscopic cholecystectomy

Objective To study the preemptive analgesic effect of flurbiprofen axetil injection in the patients undergoing laparoscopic cholecystectomy.Methods Sixty patients undergoing laparoscopic cholecystectomy were randomized to three groups with 20 cases each. The patients in group A were injected intravenously flurbiprofen axetil 50mg, and those in group B flurbiprofen xafon 8mg before intubation. The patients in group C was given intravenous flurbiprofen axetil injection 50mg at the end of surgery. The analgesic effect was evaluated by VAS score at 0,1,4,8 and 12h after surgery, and the postoperative 24h total analgesic effect, the amount of analgesic drug used postoperatively and the side effects were recorded.Results VAS scores of group C were significantly higher than those of group A and B at all time points (P0.05), except for 12h after the surgery. VAS scores of group B were higher than those of group A at the time point of 0h (P0.05). The value of total 24h analgesic effect after surgery was significantly lower in group A and B than that in group C(P0.05).The side effects of three groups were similar.Conclusion Preemptive analgesia with flurbiprofen axetil for postoperative analgesia is effective, convenient and safe with less side effect in the patients undergoing laparoscopic cholecystectomy.