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Colorimetric rate method for the determination of creatinine as implemented by the Beckman Creatinine Analyzer 2.

Orlando Flores, Ling Sun, N.D. Vaziri, D S Miyada

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Abstract

We evaluated the performance characteristics of the Beckman Creatinine Analyzer 2, a kinetic colorimetric analyzer which utilizes a modified Jaffé reagent. The instrument gave linear measurements to at least 300 mg/L and its within-run precision on a 50 mg/l creatinine standard was 1.1%. Its between-day precision on the 50 mg/L creatinine standard was less than 5.0%. Its results correlated well with those from the manual Jaffé. CentrifiChem System 400, TechniconTM SMATM 6/60 System, and TraceTM systems I and III. Interferences from 19 possible serum constituents and 32 drugs were almost nonexistent. The extended linear range of the Creatinine Analyzer 2 allowed the direct assay of samples from patients undergoing periodic hemodialysis.

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What this paper is about

We evaluated the performance characteristics of the Beckman Creatinine Analyzer 2, a kinetic colorimetric analyzer which utilizes a modified Jaffé reagent. The instrument gave linear measurements to at least 300 mg/L and its within-run precision on a 50 mg/l creatinine standard was 1.1%. Its between-day precision on the 50 mg/L creatinine standard was less than 5.0%. Its results correlated well with those from the manual Jaffé. CentrifiChem System 400, TechniconTM SMATM 6/60 System, and TraceTM systems I and III. Interferences from 19 possible serum constituents and 32 drugs were almost nonexistent. The extended linear range of the Creatinine Analyzer 2 allowed the direct assay of samples from patients undergoing periodic hemodialysis.

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Available abstract

We evaluated the performance characteristics of the Beckman Creatinine Analyzer 2, a kinetic colorimetric analyzer which utilizes a modified Jaffé reagent. The instrument gave linear measurements to at least 300 mg/L and its within-run precision on a 50 mg/l creatinine standard was 1.1%. Its between-day precision on the 50 mg/L creatinine standard was less than 5.0%. Its results correlated well with those from the manual Jaffé. CentrifiChem System 400, TechniconTM SMATM 6/60 System, and TraceTM systems I and III. Interferences from 19 possible serum constituents and 32 drugs were almost nonexistent. The extended linear range of the Creatinine Analyzer 2 allowed the direct assay of samples from patients undergoing periodic hemodialysis.

Key concepts: Spectrum analyzer, Creatinine, Chromatography, Linear range, Chemistry, Reagent, Reproducibility, Analytical Chemistry (journal)

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Colorimetric rate method for the determination of creatinine as implemented by the Beckman Creatinine Analyzer 2. — Research Paper | ScholarLens