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THE EFFECTS OF IONIZING RADIATION ON CALCIUM METABOLISM IN BONES
A Zuppinger, W Minder
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Abstract
BS>The effect of irradiation on the calcium metabolism in the bones of grownup rats was studied. 2 to 4 days following oral administration there are constant contents of the easy exchangeable calcium compenent in the bone. Following irradiation with 2000 r (250 kv, 0.25 mm Cu) there is a fast decrease of the calcium contents to 70% of the initial value. Then a gradual decrease to 50% within 6 weeks following the irradiation occurs. Following an irradiation up to 4000 r the calcium uptake reaches a limit at 64%, which is only little below the value following irradiation with 2000 r. In the unirradiated control extremity an indirect reversible effect is found during the first week. Electrons of 30 Mev cause much less bone damage. Even under consideration of equal absorbed energy the relative biological effectiveness is 0.6. (auth)