Bioactivity of Ganoderma lucidum and optimization of mycelial fermentation conditions

Ganoderma lucidum is a very precious traditional Chinese medicine. It has good pharmacological effects because of its polysaccharides, triterpenoids and other biological activities. Ganoderma lucidum mycelium is rich in Ganoderma lucidum polysaccharides and other substances, but it is difficult to obtain under natural conditions, so it is generally obtained through artificial inoculation or fermentation. Therefore, it is imperative to optimize the mycelium fermentation conditions. The range of fermentation time, temperature and pH of response surface analysis was determined by single factor experiment. The optimal fermentation conditions were fermentation temperature 28℃, pH=7, fermentation time 7 days, and mycelium biomass of (7±0.1) g/L. The results provide data reference for better utilization and development of Ganoderma lucidum.