Death receptor-dependent apoptosis and cell cycle delay induced by bioymifi in human cervical cancer cells
Ahmet Altun, Zeynep Deniz Şahin İnan, Fatih Yulak
Abstract
Ahmet Altun, Zeynep Deniz Şahin İnan, Fatih Yulak
Abstract
value (11.75μM) against HeLa cells. The cell cycle analysis demonstrated the increase of Bioymifi cured HeLa cells in the S phase. And also, 11.75µM of Bioymifi caused a significantly higher apoptotic effect compared to control. In addition, in vitro immunofluorescence experiments of this study represented that Bioymifi reduced Ki-67 localization in HeLa cells. Bioymifi has significantly anticancer actions in Human cervix cancer in vitro and can be combined with standard treatment.
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value (11.75μM) against HeLa cells. The cell cycle analysis demonstrated the increase of Bioymifi cured HeLa cells in the S phase. And also, 11.75µM of Bioymifi caused a significantly higher apoptotic effect compared to control. In addition, in vitro immunofluorescence experiments of this study represented that Bioymifi reduced Ki-67 localization in HeLa cells. Bioymifi has significantly anticancer actions in Human cervix cancer in vitro and can be combined with standard treatment.
Key concepts: HeLa, DAPI, Apoptosis, Flow cytometry, Cell cycle, Annexin, Cisplatin, Cancer cell