Experimental study on relationship of hyaluronic acid and transforming growth factor-β1 with different TCM syndromes of liver fibrosis.

Objective:To observe the relationship of Hyaluronic Acid and transforming growth factor-β1 with different TCM syndromes of liver fibrosis. Methods:All rats of model groups were treated by CCl4 to establish the liver fibrosis model. Besides CCl4,the rats of liver-stagnation and spleen-deficiency group were treated by stimulating tails with forceps clip and gastric infusion of rhubarb decoction,and the rats of qi-deficiency and blood-stasis group were treated by the method of swimming-fatigue. Then every group was intervened by the relevant medicine. After all treatments,the HA and TGF-β1 in serum were examined. Results:The HA and TGF-β1 of model groups were significantly higher than those of the control group(P0.05 or P0.01) ,especially the qi deficiency and blood stasis group. After therapy,indexes of therapy groups relieved in different degrees. Conclusions:The HA and TGF-β1 closely relate with liver fibrosis,which can be one of indexes to differentiate syndrome,judge the state of illness and guide therapy.