Lower respiratory tract infection of the elderly Enterobacteriaceae bacteria ESBLs detection and analysis of relevant factors

Objective To explore common ESBLs producing Enterobacteriaceae bacteria drug-resistance and resistance characteristics in the infected lower respiratory tract of the elderly,as well as risk factors of the ESBLs bacteria infection in the patients.Methods From April 2007 to August 2008,the bacteria of Enterobacteriaceae separated from the elderly infected lower respiratory tract were identified by BIOMERIEUX ATB1525 microbial analyzer,ESBLs phenotype and drug sensitivity were detected.Results In the detected Enterobacteriaceae bacteria,ESBLs positive rate was 41.3%,Escherichia coli,Klebsiella pneumoniae and Enterobacter cloacae of the enzyme production rates were 41.9%,51.9% and 35.1%,respectively.Conclusion All the ESBLs strains were sensitive to carbapenems,The resistance rate to most antibiotics was much higher than that of the non-ESBLs strains.The risk factors for ESBLs bacteria infection are long-term use of third-generation cephalosporins and immunosuppressive agents,and the susceptible patients may suffer from ICU,catheterization,major surgery,chronic wasting disease.For the treatment of ESBLs bacteria infection,imipenem or β-lactamase inhibitor of the complex might be chosen.